Lysosomes in hepatomas

Lysosomes

I have followed the lysosome field since it was proposed as a concept by deDuve and his co-workers in 1955 and find this collection of papers by workers in that field an interesting addition that has many sparkling con-addition, of course, to deDuve, to name a few) but it also has several several shortcomings. For the uninitiated (and there are surprisingly many for whom "lysosome" is a new wor...

Lysosomes

Figure 1. Lysosome fusion. Lysosomes fuse with late endosomes to form endolysosomes, which are major sites of acid hydrolase activity and the digestion of endocytosed cargo. Equivalent fusions of lysosomes with phagosomes or autophagosomes can also occur (not shown in detail). Lysosomes can be reformed from endolysosomes and autolysosomes via poorly understood fi ssion and maturation processes....

Comparative Biochemistry of Hepatomas

Hepatoma 5138 as compared with liver showed a marked deficiency in incorporation of labeled carbon into glycogen, CO2, and fatty acids; however, lactate production was normal. The lesion in glycogenesis agrees with the decreased phosphoglucomutase activity of this tumor. Incubation of hepatoma slices with pyruvate showed markedly depressed glucose production, revealing a decrease in gluconeogen...

Microbodies of Morris hepatomas.

SUMMARY The structure of microbodies, when present, and the activities of three microbody enzymes (catalase, urate oxidase, and D-amino acid oxidase) were studied in 35 transplantable hepatomas. Microbodies are absent in hepatomas 3683, 7794A, and BRL-4-C-3. The number, size, and often the internal structures of microbodies in the other hepatomas generally reflect the growth rates and, to a cer...

Lysosomes in cancer cells.